Targeting FVIII expression to endothelial cells regenerates a releasable pool of FVIII and restores hemostasis in a mouse model of hemophilia A

The natural cell type(s) that synthesize and release factor VIII (FVIII) into the circulation are still not known with certainty. In vitro studies indicate that artificial expression of FVIII in endothelial cells produces an intracellular pool of FVIII that can be mobilized together with its carrier...

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Autores principales: Shi, Qizhen, Fahs, Scot A., Kuether, Erin L., Cooley, Brian C., Weiler, Hartmut, Montgomery, Robert R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974610/
https://ncbi.nlm.nih.gov/pubmed/20606161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-272419
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