Induction of activated T follicular helper cells is critical for anti-FVIII inhibitor development in hemophilia A mice

The development of neutralizing anti-FVIII antibodies (inhibitors) is a major complication of FVIII protein replacement therapy in patients with hemophilia A (HA). Although multiple lines of evidence indicate that the immune response against FVIII is CD4 T-cell–dependent and many FVIII-derived CD4 e...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Jing, Weiqing, Chen, Juan, Cai, Yuanhua, Chen, Yingyu, Schroeder, Jocelyn A., Johnson, Bryon D., Cui, Weiguo, Shi, Qizhen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6849959/
https://ncbi.nlm.nih.gov/pubmed/31648333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000650
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