Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models

Processing by the proprotein convertase furin is believed to be critical for the biological activity of multiple proteins involved in hemostasis, including coagulation factor VIII (FVIII). This belief prompted the retention of the furin recognition motif (amino acids 1645–1648) in the design of B-do...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:JCI Insight
मुख्य लेखकों: Siner, Joshua I., Samelson-Jones, Benjamin J., Crudele, Julie M., French, Robert A., Lee, Benjamin J., Zhou, Shanzhen, Merricks, Elizabeth, Raymer, Robin, Nichols, Timothy C., Camire, Rodney M., Arruda, Valder R.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Clinical Investigation 2016
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053153/
https://ncbi.nlm.nih.gov/pubmed/27734034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89371
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