Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models

Processing by the proprotein convertase furin is believed to be critical for the biological activity of multiple proteins involved in hemostasis, including coagulation factor VIII (FVIII). This belief prompted the retention of the furin recognition motif (amino acids 1645–1648) in the design of B-do...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:JCI Insight
Päätekijät: Siner, Joshua I., Samelson-Jones, Benjamin J., Crudele, Julie M., French, Robert A., Lee, Benjamin J., Zhou, Shanzhen, Merricks, Elizabeth, Raymer, Robin, Nichols, Timothy C., Camire, Rodney M., Arruda, Valder R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2016
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053153/
https://ncbi.nlm.nih.gov/pubmed/27734034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89371
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