Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models

Processing by the proprotein convertase furin is believed to be critical for the biological activity of multiple proteins involved in hemostasis, including coagulation factor VIII (FVIII). This belief prompted the retention of the furin recognition motif (amino acids 1645–1648) in the design of B-do...

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Bibliografische gegevens
Gepubliceerd in:JCI Insight
Hoofdauteurs: Siner, Joshua I., Samelson-Jones, Benjamin J., Crudele, Julie M., French, Robert A., Lee, Benjamin J., Zhou, Shanzhen, Merricks, Elizabeth, Raymer, Robin, Nichols, Timothy C., Camire, Rodney M., Arruda, Valder R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053153/
https://ncbi.nlm.nih.gov/pubmed/27734034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89371
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