Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models

Processing by the proprotein convertase furin is believed to be critical for the biological activity of multiple proteins involved in hemostasis, including coagulation factor VIII (FVIII). This belief prompted the retention of the furin recognition motif (amino acids 1645–1648) in the design of B-do...

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Enregistré dans:
Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Siner, Joshua I., Samelson-Jones, Benjamin J., Crudele, Julie M., French, Robert A., Lee, Benjamin J., Zhou, Shanzhen, Merricks, Elizabeth, Raymer, Robin, Nichols, Timothy C., Camire, Rodney M., Arruda, Valder R.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053153/
https://ncbi.nlm.nih.gov/pubmed/27734034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89371
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