LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma

Germline mutations in LKB1 (STK11) are associated with the Peutz-Jeghers syndrome (PJS), which includes aberrant mucocutaneous pigmentation, and somatic LKB1 mutations occur in 10% of cutaneous melanoma. By somatically inactivating Lkb1 with K-Ras activation (±p53 loss) in murine melanocytes, we obs...

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Hauptverfasser: Liu, Wenjin, Monahan, Kimberly B., Pfefferle, Adam D., Shimamura, Takeshi, Sorrentino, Jessica, Chan, Keefe T., Roadcap, David W., Ollila, David W., Thomas, Nancy E., Castrillon, Diego H., Miller, C. Ryan, Perou, Charles M., Wong, Kwok-Kin, Bear, James E., Sharpless, Norman E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660964/
https://ncbi.nlm.nih.gov/pubmed/22698401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.03.048
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