Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy

Por Pfefferle, Adam D., Spike, Benjamin T., Wahl, Geoff M., Perou, Charles M.
Publicado no Breast Cancer Res Treat (2015)

A Potential Role for Glucose Transporters in the Evolution of Human Brain Size

Por Fedrigo, Olivier, Pfefferle, Adam D., Babbitt, Courtney C., Haygood, Ralph, Wall, Christine E., Wray, Gregory A.
Publicado em 2011

Oncogenic PI3K Mutations Lead to NF-κB-dependent Cytokine Expression Following Growth Factor Deprivation

Por Hutti, Jessica E., Pfefferle, Adam D., Russell, Sean C., Sircar, Mayukh, Perou, Charles M., Baldwin, Albert S.
Publicado em 2012

Expression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential

Por Knezevic, Jana, Pfefferle, Adam D., Petrovic, Ivana, Greene, Stephanie B., Perou, Charles M., Rosen, Jeffrey M.
Publicado no Oncogene (2015)

A Pipeline to Determine RT-QPCR Control Genes for Evolutionary Studies: Application to Primate Gene Expression across Multiple Tissues

Por Fedrigo, Olivier, Warner, Lisa R., Pfefferle, Adam D., Babbitt, Courtney C., Cruz-Gordillo, Peter, Wray, Gregory A.
Publicado em 2010

c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression

Por Cantrell, Michael A., Ebelt, Nancy D., Pfefferle, Adam D., Perou, Charles M., Van Den Berg, Carla Lynn
Publicado no Oncotarget (2015)

Both Noncoding and Protein-Coding RNAs Contribute to Gene Expression Evolution in the Primate Brain

Por Babbitt, Courtney C., Fedrigo, Olivier, Pfefferle, Adam D., Boyle, Alan P., Horvath, Julie E., Furey, Terrence S., Wray, Gregory A.
Publicado em 2010

Comparative expression analysis of the phosphocreatine circuit in extant primates: implications for human brain evolution

Por Pfefferle, Adam D., Warner, Lisa R., Wang, Catrina W., Nielsen, William J., Babbitt, Courtney C., Fedrigo, Olivier, Wray, Gregory A.
Publicado em 2010

Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers

Por Pfefferle, Adam D., Agrawal, Yash N., Koboldt, Daniel C., Kanchi, Krishna L., Herschkowitz, Jason I., Mardis, Elaine R., Rosen, Jeffrey M., Perou, Charles M.
Publicado no Dis Model Mech (2016)

Endothelial-like properties of claudin-low breast cancer cells promote tumor vascular permeability and metastasis

Por Harrell, J. Chuck, Pfefferle, Adam D., Zalles, Nicole, Prat, Aleix, Fan, Cheng, Khramtsov, Andrey, Olopade, Olufunmilayo I., Troester, Melissa A., Dudley, Andrew C., Perou, Charles M.
Publicado em 2013

Comparative Oncogenomics Implicates the Neurofibromin 1 Gene (NF1) as a Breast Cancer Driver

Por Wallace, Marsha D., Pfefferle, Adam D., Shen, Lishuang, McNairn, Adrian J., Cerami, Ethan G., Fallon, Barbara L., Rinaldi, Vera D., Southard, Teresa L., Perou, Charles M., Schimenti, John C.
Publicado em 2012

Conditional loss of ErbB3 delays mammary gland hyperplasia induced by mutant PIK3CA without affecting mammary tumor latency, gene expression or signaling

Por Young, Christian D., Pfefferle, Adam D., Owens, Philip, Kuba, María G., Rexer, Brent N., Balko, Justin M., Sánchez, Violeta, Cheng, Hailing, Perou, Charles M., Zhao, Jean J., Cook, Rebecca S., Arteaga, Carlos L.
Publicado em 2013

Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies

Por Hanker, Ariella B., Pfefferle, Adam D., Balko, Justin M., Kuba, María Gabriela, Young, Christian D., Sánchez, Violeta, Sutton, Cammie R., Cheng, Hailing, Perou, Charles M., Zhao, Jean J., Cook, Rebecca S., Arteaga, Carlos L.
Publicado em 2013

Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts

Por Pfefferle, Adam D, Herschkowitz, Jason I, Usary, Jerry, Harrell, Joshua Chuck, Spike, Benjamin T, Adams, Jessica R, Torres-Arzayus, Maria I, Brown, Myles, Egan, Sean E, Wahl, Geoffrey M, Rosen, Jeffrey M, Perou, Charles M
Publicado em 2013

LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma

Por Liu, Wenjin, Monahan, Kimberly B., Pfefferle, Adam D., Shimamura, Takeshi, Sorrentino, Jessica, Chan, Keefe T., Roadcap, David W., Ollila, David W., Thomas, Nancy E., Castrillon, Diego H., Miller, C. Ryan, Perou, Charles M., Wong, Kwok-Kin, Bear, James E., Sharpless, Norman E.
Publicado em 2012

Combined PI3K/mTOR and MEK Inhibition Provides Broad Antitumor Activity in Faithful Murine Cancer Models

Por Roberts, Patrick J., Usary, Jerry E., Darr, David B., Dillon, Patrick M., Pfefferle, Adam D., Whittle, Martin C., Duncan, James S., Johnson, Soren M., Combest, Austin J., Jin, Jian, Zamboni, William C., Johnson, Gary L., Perou, Charles M., Sharpless, Norman E.
Publicado em 2012