Combined PI3K/mTOR and MEK Inhibition Provides Broad Antitumor Activity in Faithful Murine Cancer Models

PURPOSE: Anticancer drug development is inefficient, but genetically engineered murine models (GEMM) and orthotopic, syngeneic transplants (OST) of cancer may offer advantages to in vitro and xenograft systems. EXPERIMENTAL DESIGN: We assessed the activity of 16 treatment regimens in a RAS-driven, I...

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Bibliografiske detaljer
Main Authors: Roberts, Patrick J., Usary, Jerry E., Darr, David B., Dillon, Patrick M., Pfefferle, Adam D., Whittle, Martin C., Duncan, James S., Johnson, Soren M., Combest, Austin J., Jin, Jian, Zamboni, William C., Johnson, Gary L., Perou, Charles M., Sharpless, Norman E.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715399/
https://ncbi.nlm.nih.gov/pubmed/22872574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0563
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