Genetically Engineered Cancer Models, But Not Xenografts, Faithfully Predict Anticancer Drug Exposure in Melanoma Tumors

BACKGROUND. Rodent studies are a vital step in the development of novel anticancer therapeutics and are used in pharmacokinetic (PK), toxicology, and efficacy studies. Traditionally, anticancer drug development has relied on xenograft implantation of human cancer cell lines in immunocompromised mice...

詳細記述

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書誌詳細
主要な著者: Combest, Austin J., Roberts, Patrick J., Dillon, Patrick M., Sandison, Katie, Hanna, Suzan K., Ross, Charlene, Habibi, Sohrab, Zamboni, Beth, Müller, Markus, Brunner, Martin, Sharpless, Norman E., Zamboni, William C.
フォーマット: Artigo
言語:Inglês
出版事項: AlphaMed Press 2012
主題:
Melanoma and Cutaneous Malignancies
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481896/
https://ncbi.nlm.nih.gov/pubmed/22993143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2012-0274
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