Genetically Engineered Cancer Models, But Not Xenografts, Faithfully Predict Anticancer Drug Exposure in Melanoma Tumors

BACKGROUND. Rodent studies are a vital step in the development of novel anticancer therapeutics and are used in pharmacokinetic (PK), toxicology, and efficacy studies. Traditionally, anticancer drug development has relied on xenograft implantation of human cancer cell lines in immunocompromised mice...

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Autors principals: Combest, Austin J., Roberts, Patrick J., Dillon, Patrick M., Sandison, Katie, Hanna, Suzan K., Ross, Charlene, Habibi, Sohrab, Zamboni, Beth, Müller, Markus, Brunner, Martin, Sharpless, Norman E., Zamboni, William C.
Format: Artigo
Idioma:Inglês
Publicat: AlphaMed Press 2012
Matèries:
Melanoma and Cutaneous Malignancies
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481896/
https://ncbi.nlm.nih.gov/pubmed/22993143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2012-0274
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