Genetically Engineered Cancer Models, But Not Xenografts, Faithfully Predict Anticancer Drug Exposure in Melanoma Tumors

BACKGROUND. Rodent studies are a vital step in the development of novel anticancer therapeutics and are used in pharmacokinetic (PK), toxicology, and efficacy studies. Traditionally, anticancer drug development has relied on xenograft implantation of human cancer cell lines in immunocompromised mice...

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Detalhes bibliográficos
Main Authors: Combest, Austin J., Roberts, Patrick J., Dillon, Patrick M., Sandison, Katie, Hanna, Suzan K., Ross, Charlene, Habibi, Sohrab, Zamboni, Beth, Müller, Markus, Brunner, Martin, Sharpless, Norman E., Zamboni, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2012
Assuntos:
Melanoma and Cutaneous Malignancies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481896/
https://ncbi.nlm.nih.gov/pubmed/22993143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2012-0274
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