Genetically Engineered Cancer Models, But Not Xenografts, Faithfully Predict Anticancer Drug Exposure in Melanoma Tumors

BACKGROUND. Rodent studies are a vital step in the development of novel anticancer therapeutics and are used in pharmacokinetic (PK), toxicology, and efficacy studies. Traditionally, anticancer drug development has relied on xenograft implantation of human cancer cell lines in immunocompromised mice...

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Bibliographische Detailangaben
Hauptverfasser: Combest, Austin J., Roberts, Patrick J., Dillon, Patrick M., Sandison, Katie, Hanna, Suzan K., Ross, Charlene, Habibi, Sohrab, Zamboni, Beth, Müller, Markus, Brunner, Martin, Sharpless, Norman E., Zamboni, William C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: AlphaMed Press 2012
Schlagworte:
Melanoma and Cutaneous Malignancies
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481896/
https://ncbi.nlm.nih.gov/pubmed/22993143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2012-0274
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