Genetically Engineered Cancer Models, But Not Xenografts, Faithfully Predict Anticancer Drug Exposure in Melanoma Tumors

BACKGROUND. Rodent studies are a vital step in the development of novel anticancer therapeutics and are used in pharmacokinetic (PK), toxicology, and efficacy studies. Traditionally, anticancer drug development has relied on xenograft implantation of human cancer cell lines in immunocompromised mice...

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Détails bibliographiques
Auteurs principaux: Combest, Austin J., Roberts, Patrick J., Dillon, Patrick M., Sandison, Katie, Hanna, Suzan K., Ross, Charlene, Habibi, Sohrab, Zamboni, Beth, Müller, Markus, Brunner, Martin, Sharpless, Norman E., Zamboni, William C.
Format: Artigo
Langue:Inglês
Publié: AlphaMed Press 2012
Sujets:
Melanoma and Cutaneous Malignancies
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481896/
https://ncbi.nlm.nih.gov/pubmed/22993143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2012-0274
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