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c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression

Breast cancer is a heterogeneous disease with several subtypes carrying unique prognoses. Patients with differentiated luminal tumors experience better outcomes, while effective treatments are unavailable for poorly differentiated tumors, including the basal-like subtype. Mechanisms governing mammar...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cantrell, Michael A., Ebelt, Nancy D., Pfefferle, Adam D., Perou, Charles M., Van Den Berg, Carla Lynn
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4494910/
https://ncbi.nlm.nih.gov/pubmed/25970777
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