LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma

Germline mutations in LKB1 (STK11) are associated with the Peutz-Jeghers syndrome (PJS), which includes aberrant mucocutaneous pigmentation, and somatic LKB1 mutations occur in 10% of cutaneous melanoma. By somatically inactivating Lkb1 with K-Ras activation (±p53 loss) in murine melanocytes, we obs...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Liu, Wenjin, Monahan, Kimberly B., Pfefferle, Adam D., Shimamura, Takeshi, Sorrentino, Jessica, Chan, Keefe T., Roadcap, David W., Ollila, David W., Thomas, Nancy E., Castrillon, Diego H., Miller, C. Ryan, Perou, Charles M., Wong, Kwok-Kin, Bear, James E., Sharpless, Norman E.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660964/
https://ncbi.nlm.nih.gov/pubmed/22698401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.03.048
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars