The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues

Germline mutations in the LKB1 gene (also known as STK11) cause the Peutz-Jeghers Syndrome, and somatic loss of LKB1 has emerged as causal event in a wide range of human malignancies, including melanoma, lung cancer, and cervical cancer. The LKB1 protein is a serine-threonine kinase that phosphoryla...

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Detalhes bibliográficos
Main Authors: Nakada, Yuji, Stewart, Thomas G., Peña, Christopher G., Zhang, Song, Zhao, Ni, Bardeesy, Nabeel, Sharpless, Norman E., Wong, Kwok-Kin, Hayes, D. Neil, Castrillon, Diego H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783464/
https://ncbi.nlm.nih.gov/pubmed/24086281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073449
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