Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy

Endometrial cancer – the most common malignancy of the female reproductive tract – arises from the specialized epithelial cells that line the inner surface of the uterus. Although significant advances have been made in our understanding of this disease in recent years, one significant limitation has...

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Bibliographic Details
Main Authors: Contreras, Cristina M., Akbay, Esra A., Gallardo, Teresa D., Haynie, J. Marshall, Sharma, Sreenath, Tagao, Osamu, Bardeesy, Nabeel, Takahashi, Masaya, Settleman, Jeff, Wong, Kwok-Kin, Castrillon, Diego H.
Format: Artigo
Language:Inglês
Published: The Company of Biologists Limited 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869492/
https://ncbi.nlm.nih.gov/pubmed/20142330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.004440
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