Integrative genomic and proteomic analyses identify targets for Lkb1 deficient metastatic lung tumors

In mice, Lkb1 deletion and activation of Kras(G12D) results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and metastatic de novo lung cancers with integrated genomic and proteomic profiles and have identified gene and phosphoprotein signatures...

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Hauptverfasser: Carretero, Julian, Shimamura, Takeshi, Rikova, Klarisa, Jackson, Autumn L., Wilkerson, Matthew D., Borgman, Christa L., Buttarazzi, Matthew S., Sanofsky, Benjamin A., McNamara, Kate L., Brandstetter, Kathleyn A., Walton, Zandra E., Gu, Ting-Lei, Silva, Jeffrey C., Crosby, Katherine, Shapiro, Geoffrey I., Maira, Michel, Ji, Hongbin, Castrillon, Diego H., Kim, Carla F, García-Echeverría, Carlos, Bardeesy, Nabeel, Sharpless, Norman E., Hayes, Neil D., Kim, William Y., Engelman, Jeffrey A., Wong, Kwok-Kin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901842/
https://ncbi.nlm.nih.gov/pubmed/20541700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.04.026
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