LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues

Somatic inactivation of the serine/threonine kinase gene STK11/LKB1/PAR-4 occurs in a variety of cancers, including ∼10% of melanoma. However, how the loss of LKB1 activity facilitates melanoma invasion and metastasis remains poorly understood. In LKB1-null cells derived from an autochthonous murine...

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Detalhes bibliográficos
Main Authors: Chan, Keefe T., Asokan, Sreeja B., King, Samantha J., Bo, Tao, Dubose, Evan S., Liu, Wenjin, Berginski, Matthew E., Simon, Jeremy M., Davis, Ian J., Gomez, Shawn M., Sharpless, Norman E., Bear, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210439/
https://ncbi.nlm.nih.gov/pubmed/25349262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201404067
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