Conditional loss of ErbB3 delays mammary gland hyperplasia induced by mutant PIK3CA without affecting mammary tumor latency, gene expression or signaling

Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of phosphatidylinositol-3 kinase (PI3K), have been shown to transform mammary epithelial cells (MECs). Studies suggest this transforming activity requires binding of mutant p110α via p85 to phosphorylated YXXM motifs in activated rec...

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Detalhes bibliográficos
Main Authors: Young, Christian D., Pfefferle, Adam D., Owens, Philip, Kuba, María G., Rexer, Brent N., Balko, Justin M., Sánchez, Violeta, Cheng, Hailing, Perou, Charles M., Zhao, Jean J., Cook, Rebecca S., Arteaga, Carlos L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702683/
https://ncbi.nlm.nih.gov/pubmed/23633485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4579
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