Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies

Human epidermal growth factor receptor 2 (HER2; ERBB2) amplification and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) mutations often co-occur in breast cancer. Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway has been shown to correlate wit...

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Main Authors: Hanker, Ariella B., Pfefferle, Adam D., Balko, Justin M., Kuba, María Gabriela, Young, Christian D., Sánchez, Violeta, Sutton, Cammie R., Cheng, Hailing, Perou, Charles M., Zhao, Jean J., Cook, Rebecca S., Arteaga, Carlos L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761610/
https://ncbi.nlm.nih.gov/pubmed/23940356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303204110
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