In situ single cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2(+) breast cancer

Detection of minor genetically distinct subpopulations within tumors is a key challenge in cancer genomics. Here we report STAR-FISH (Specific-To-Allele PCR – FISH), a novel method for the combined detection of single nucleotide and copy number alterations in single cells in intact archived tissues....

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Janiszewska, Michalina, Liu, Lin, Almendro, Vanessa, Kuang, Yanan, Paweletz, Cloud, Sakr, Rita A., Weigelt, Britta, Hanker, Ariella B., Chandarlapaty, Sarat, King, Tari A., Reis-Filho, Jorge S., Arteaga, Carlos L., Park, So Yeon, Michor, Franziska, Polyak, Kornelia
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4589505/
https://ncbi.nlm.nih.gov/pubmed/26301495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3391
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