ErbB3 downregulation enhances luminal breast tumor response to antiestrogens

Aberrant regulation of the erythroblastosis oncogene B (ErbB) family of receptor tyrosine kinases (RTKs) and their ligands is common in human cancers. ErbB3 is required in luminal mammary epithelial cells (MECs) for growth and survival. Since breast cancer phenotypes may reflect biological traits of...

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Bibliographic Details
Main Authors: Morrison, Meghan M., Hutchinson, Katherine, Williams, Michelle M., Stanford, Jamie C., Balko, Justin M., Young, Christian, Kuba, Maria G., Sánchez, Violeta, Williams, Andrew J., Hicks, Donna J., Arteaga, Carlos L., Prat, Aleix, Perou, Charles M., Earp, H. Shelton, Massarweh, Suleiman, Cook, Rebecca S.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784526/
https://ncbi.nlm.nih.gov/pubmed/23999432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66764
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