ErbB3 downregulation enhances luminal breast tumor response to antiestrogens

Aberrant regulation of the erythroblastosis oncogene B (ErbB) family of receptor tyrosine kinases (RTKs) and their ligands is common in human cancers. ErbB3 is required in luminal mammary epithelial cells (MECs) for growth and survival. Since breast cancer phenotypes may reflect biological traits of...

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Hlavní autoři: Morrison, Meghan M., Hutchinson, Katherine, Williams, Michelle M., Stanford, Jamie C., Balko, Justin M., Young, Christian, Kuba, Maria G., Sánchez, Violeta, Williams, Andrew J., Hicks, Donna J., Arteaga, Carlos L., Prat, Aleix, Perou, Charles M., Earp, H. Shelton, Massarweh, Suleiman, Cook, Rebecca S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784526/
https://ncbi.nlm.nih.gov/pubmed/23999432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66764
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