The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium

ErbB3 harbors weak kinase activity, but strongly activates downstream phosphatidylinositol 3-kinase/Akt signaling through heterodimerization with and activation by other ErbB receptor tyrosine kinases. We report here that ErbB3 loss in the luminal mammary epithelium of mice impaired Akt and MAPK sig...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Balko, Justin M., Miller, Todd W., Morrison, Meghan M., Hutchinson, Katherine, Young, Christian, Rinehart, Cammie, Sánchez, Violeta, Jee, David, Polyak, Kornelia, Prat, Aleix, Perou, Charles M., Arteaga, Carlos L., Cook, Rebecca S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252958/
https://ncbi.nlm.nih.gov/pubmed/22178756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115802109
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados