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ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

Both ErbB1 and ErbB2 are overexpressed or amplified in breast tumours. To examine the effects of activating ErbB receptors in a context that mimics polarized epithelial cells in vivo, we activated ErbB1 and ErbB2 homodimers in preformed, growth-arrested mammary acini cultured in three-dimensional ba...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Muthuswamy, Senthil K., Li, Dongmei, Lelievre, Sophie, Bissell, Mina J., Brugge, Joan S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2001
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952547/
https://ncbi.nlm.nih.gov/pubmed/11533657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb0901-785
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