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Shc is required for ErbB2 induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity
Amplification and overexpression of ErbB2 strongly correlates with aggressive breast cancers. A deeper understanding of pathways downstream of ErbB2 signaling that are required for transformation of human mammary epithelial cells will identify novel strategies for therapeutic intervention in breast...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2948752/ https://ncbi.nlm.nih.gov/pubmed/19826412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.312 |
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