The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium

ErbB3 harbors weak kinase activity, but strongly activates downstream phosphatidylinositol 3-kinase/Akt signaling through heterodimerization with and activation by other ErbB receptor tyrosine kinases. We report here that ErbB3 loss in the luminal mammary epithelium of mice impaired Akt and MAPK sig...

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Hauptverfasser: Balko, Justin M., Miller, Todd W., Morrison, Meghan M., Hutchinson, Katherine, Young, Christian, Rinehart, Cammie, Sánchez, Violeta, Jee, David, Polyak, Kornelia, Prat, Aleix, Perou, Charles M., Arteaga, Carlos L., Cook, Rebecca S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252958/
https://ncbi.nlm.nih.gov/pubmed/22178756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115802109
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