ErbB3 downregulation enhances luminal breast tumor response to antiestrogens

Aberrant regulation of the erythroblastosis oncogene B (ErbB) family of receptor tyrosine kinases (RTKs) and their ligands is common in human cancers. ErbB3 is required in luminal mammary epithelial cells (MECs) for growth and survival. Since breast cancer phenotypes may reflect biological traits of...

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Detalhes bibliográficos
Main Authors: Morrison, Meghan M., Hutchinson, Katherine, Williams, Michelle M., Stanford, Jamie C., Balko, Justin M., Young, Christian, Kuba, Maria G., Sánchez, Violeta, Williams, Andrew J., Hicks, Donna J., Arteaga, Carlos L., Prat, Aleix, Perou, Charles M., Earp, H. Shelton, Massarweh, Suleiman, Cook, Rebecca S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784526/
https://ncbi.nlm.nih.gov/pubmed/23999432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66764
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