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Automated design of ligands to polypharmacological profiles
The clinical efficacy and safety of a drug is determined by its activity profile across multiple proteins in the proteome. However, designing drugs with a specific multi-target profile is both complex and difficult. Therefore methods to rationally design drugs a priori against profiles of multiple p...
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Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Artigo |
Lenguaje: | Inglês |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3653568/ https://ncbi.nlm.nih.gov/pubmed/23235874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11691 |
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