Automated design of ligands to polypharmacological profiles

The clinical efficacy and safety of a drug is determined by its activity profile across multiple proteins in the proteome. However, designing drugs with a specific multi-target profile is both complex and difficult. Therefore methods to rationally design drugs a priori against profiles of multiple p...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Besnard, Jérémy, Ruda, Gian Filippo, Setola, Vincent, Abecassis, Keren, Rodriguiz, Ramona M., Huang, Xi-Ping, Norval, Suzanne, Sassano, Maria F., Shin, Antony I., Webster, Lauren A., Simeons, Frederick R.C., Stojanovski, Laste, Prat, Annik, Seidah, Nabil G., Constam, Daniel B., Bickerton, G. Richard, Read, Kevin D., Wetsel, William C., Gilbert, Ian H., Roth, Bryan L., Hopkins, Andrew L.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653568/
https://ncbi.nlm.nih.gov/pubmed/23235874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11691
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares