Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

Constitutive activation of growth factor signaling pathways paradoxically triggers a cell cycle arrest known as cellular senescence. In primary cells expressing oncogenic ras, this mechanism effectively prevents cell transformation. Surprisingly, attenuation of ERK/MAP kinase signaling by genetic in...

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Autors principals: Deschênes-Simard, Xavier, Gaumont-Leclerc, Marie-France, Bourdeau, Véronique, Lessard, Frédéric, Moiseeva, Olga, Forest, Valérie, Igelmann, Sebastian, Mallette, Frédérick A., Saba-El-Leil, Marc K., Meloche, Sylvain, Saad, Fred, Mes-Masson, Anne-Marie, Ferbeyre, Gerardo
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2013
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650227/
https://ncbi.nlm.nih.gov/pubmed/23599344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.203984.112
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