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The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
Here we report that RNA interference against ATM inhibited p53 accumulation in cells expressing oncogenic STAT5 and cooperated with Rb inactivation to suppress STAT5A-induced senescence. Knocking down ATM was also effective to bypass E2F1-induced senescence and in combination with Rb inactivation, i...
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| Päätekijät: | , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Cold Spring Harbor Laboratory Press
2007
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1759898/ https://ncbi.nlm.nih.gov/pubmed/17210786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1487307 |
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