The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence

Here we report that RNA interference against ATM inhibited p53 accumulation in cells expressing oncogenic STAT5 and cooperated with Rb inactivation to suppress STAT5A-induced senescence. Knocking down ATM was also effective to bypass E2F1-induced senescence and in combination with Rb inactivation, i...

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Bibliografische gegevens
Hoofdauteurs: Mallette, Frédérick A., Gaumont-Leclerc, Marie-France, Ferbeyre, Gerardo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2007
Onderwerpen:
Research Communication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1759898/
https://ncbi.nlm.nih.gov/pubmed/17210786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1487307
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