ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

Activated Ras oncogene induces DNA-damage response by triggering reactive oxygen species (ROS) production and this is critical for oncogene-induced senescence. Until now, little connections between oncogene expression, ROS-generating NADPH oxidases and DNA-damage response have emerged from different...

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Detalhes bibliográficos
Main Authors: Weyemi, U, Lagente-Chevallier, O, Boufraqech, M, Prenois, F, Courtin, F, Caillou, B, Talbot, M, Dardalhon, M, Al Ghuzlan, A, Bidart, J-M, Schlumberger, M, Dupuy, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307059/
https://ncbi.nlm.nih.gov/pubmed/21841825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.327
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