Somatic RAS Mutations Occur in a Large Proportion of Sporadic RET-Negative Medullary Thyroid Carcinomas and Extend to a Previously Unidentified Exon

CONTEXT: Medullary thyroid carcinoma (MTC) is characterized by proto-oncogene RET mutations in almost all hereditary cases as well as in more than 40% of sporadic cases. Recently, a high prevalence of RAS mutations was reported in sporadic MTC, suggesting an alternative genetic event in sporadic MTC...

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Detalhes bibliográficos
Main Authors: Boichard, A., Croux, L., Al Ghuzlan, A., Broutin, S., Dupuy, C., Leboulleux, S., Schlumberger, M., Bidart, JM., Lacroix, L.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
JCEM Online: Advances in Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462939/
https://ncbi.nlm.nih.gov/pubmed/22865907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-2092
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