Somatic Mutations in RET Exons 12 and 15 in Sporadic Medullary Thyroid Carcinomas: Different Spectrum of Mutations in Sporadic Type from Hereditary Type

Germline mutations in the RET proto‐oncogene are responsible for multiple endocrine neoplasia type 2 (MEN 2A and 2B) and familial medullary thyroid carcinoma (FMTC). Point mutations or in‐frame deletions of exons 10, 11, 13, 14 and 16 are associated with sporadic medullary thyroid carcinoma (MTC). T...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Uchino, Shinya, Noguchi, Shiro, Yamashita, Hiroto, Sato, Mari, Adachi, Mitsuo, Yamashita, Hiroyuki, Watanabe, Shin, Ohshima, Akira, Mitsuyama, Shoshu, Iwashita, Toshihide, Takahashi, Masahide
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1999
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926019/
https://ncbi.nlm.nih.gov/pubmed/10622534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1999.tb00701.x
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