Exomic Sequencing of Medullary Thyroid Cancer Reveals Dominant and Mutually Exclusive Oncogenic Mutations in RET and RAS

CONTEXT: Medullary thyroid cancer (MTC) is a rare thyroid cancer that can occur sporadically or as part of a hereditary syndrome. OBJECTIVE: To explore the genetic origin of MTC, we sequenced the protein coding exons of approximately 21,000 genes in 17 sporadic MTCs. PATIENTS AND DESIGN: We sequence...

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Autors principals: Agrawal, Nishant, Jiao, Yuchen, Sausen, Mark, Leary, Rebecca, Bettegowda, Chetan, Roberts, Nicholas J., Bhan, Sheetal, Ho, Allen S., Khan, Zubair, Bishop, Justin, Westra, William H., Wood, Laura D., Hruban, Ralph H., Tufano, Ralph P., Robinson, Bruce, Dralle, Henning, Toledo, Sergio P. A., Toledo, Rodrigo A., Morris, Luc G. T., Ghossein, Ronald A., Fagin, James A., Chan, Timothy A., Velculescu, Victor E., Vogelstein, Bert, Kinzler, Kenneth W., Papadopoulos, Nickolas, Nelkin, Barry D., Ball, Douglas W.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2013
Matèries:
JCEM Online: Advances in Genetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565108/
https://ncbi.nlm.nih.gov/pubmed/23264394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-2703
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