Exomic Sequencing of Medullary Thyroid Cancer Reveals Dominant and Mutually Exclusive Oncogenic Mutations in RET and RAS

CONTEXT: Medullary thyroid cancer (MTC) is a rare thyroid cancer that can occur sporadically or as part of a hereditary syndrome. OBJECTIVE: To explore the genetic origin of MTC, we sequenced the protein coding exons of approximately 21,000 genes in 17 sporadic MTCs. PATIENTS AND DESIGN: We sequence...

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Detaylı Bibliyografya
Asıl Yazarlar: Agrawal, Nishant, Jiao, Yuchen, Sausen, Mark, Leary, Rebecca, Bettegowda, Chetan, Roberts, Nicholas J., Bhan, Sheetal, Ho, Allen S., Khan, Zubair, Bishop, Justin, Westra, William H., Wood, Laura D., Hruban, Ralph H., Tufano, Ralph P., Robinson, Bruce, Dralle, Henning, Toledo, Sergio P. A., Toledo, Rodrigo A., Morris, Luc G. T., Ghossein, Ronald A., Fagin, James A., Chan, Timothy A., Velculescu, Victor E., Vogelstein, Bert, Kinzler, Kenneth W., Papadopoulos, Nickolas, Nelkin, Barry D., Ball, Douglas W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Endocrine Society 2013
Konular:
JCEM Online: Advances in Genetics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565108/
https://ncbi.nlm.nih.gov/pubmed/23264394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-2703
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