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DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon Stimulation
Interferons are cytokines with potent antiviral and antiproliferative activities. We report that although a transient exposure to β-interferon induces a reversible cell cycle arrest, a sustained treatment triggers a p53-dependent senescence program. β-Interferon switched on p53 in two steps. First,...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The American Society for Cell Biology
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1415317/ https://ncbi.nlm.nih.gov/pubmed/16436515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-09-0858 |
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