Mutant lamin A links prophase to a p53 independent senescence program

Expression of oncogenes or short telomeres can trigger an anticancer response known as cellular senescence activating the p53 and RB tumor suppressor pathways. This mechanism is switched off in most tumor cells by mutations in p53 and RB signaling pathways. Surprisingly, p53 disabled tumor cells cou...

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Publicado en:Cell Cycle
Autores principales: Moiseeva, Olga, Lessard, Frédéric, Acevedo-Aquino, Mariana, Vernier, Mathieu, Tsantrizos, Youla S, Ferbeyre, Gerardo
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614274/
https://ncbi.nlm.nih.gov/pubmed/26029982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1053671
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