Mutant lamin A links prophase to a p53 independent senescence program

Expression of oncogenes or short telomeres can trigger an anticancer response known as cellular senescence activating the p53 and RB tumor suppressor pathways. This mechanism is switched off in most tumor cells by mutations in p53 and RB signaling pathways. Surprisingly, p53 disabled tumor cells cou...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Moiseeva, Olga, Lessard, Frédéric, Acevedo-Aquino, Mariana, Vernier, Mathieu, Tsantrizos, Youla S, Ferbeyre, Gerardo
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614274/
https://ncbi.nlm.nih.gov/pubmed/26029982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1053671
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