Mutant lamin A links prophase to a p53 independent senescence program

Expression of oncogenes or short telomeres can trigger an anticancer response known as cellular senescence activating the p53 and RB tumor suppressor pathways. This mechanism is switched off in most tumor cells by mutations in p53 and RB signaling pathways. Surprisingly, p53 disabled tumor cells cou...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Cycle
Main Authors: Moiseeva, Olga, Lessard, Frédéric, Acevedo-Aquino, Mariana, Vernier, Mathieu, Tsantrizos, Youla S, Ferbeyre, Gerardo
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2015
Teme:
Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614274/
https://ncbi.nlm.nih.gov/pubmed/26029982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1053671
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