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Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase

Mutants of lamin A cause diseases including the Hutchinson-Gilford progeria syndrome (HGPS) characterized by premature aging. Lamin A undergoes a series of processing reactions, including farnesylation and proteolytic cleavage of the farnesylated C-terminal domain. The role of cleavage is unknown bu...

詳細記述

保存先:
書誌詳細
出版年:Aging (Albany NY)
主要な著者: Moiseeva, Olga, Lopes-Paciencia, Stéphane, Huot, Geneviève, Lessard, Frédéric, Ferbeyre, Gerardo
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789588/
https://ncbi.nlm.nih.gov/pubmed/26922519
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