Regulation of E2Fs and senescence by PML nuclear bodies

The tumor suppressor PML (promyelocytic leukemia protein) regulates cellular senescence and terminal differentiation, two processes that implicate a permanent exit from the cell cycle. Here, we show that the mechanism by which PML induces a permanent cell cycle exit and activates p53 and senescence...

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Autors principals: Vernier, Mathieu, Bourdeau, Véronique, Gaumont-Leclerc, Marie-France, Moiseeva, Olga, Bégin, Virginie, Saad, Fred, Mes-Masson, Anne-Marie, Ferbeyre, Gerardo
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2011
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012935/
https://ncbi.nlm.nih.gov/pubmed/21205865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1975111
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