Cellular senescence and protein degradation: Breaking down cancer

Autophagy and the ubiquitin–proteasome pathway (UPP) are the major protein degradation systems in eukaryotic cells. Whereas the former mediate a bulk nonspecific degradation, the UPP allows a rapid degradation of specific proteins. Both systems have been shown to play a role in tumorigenesis, and th...

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Main Authors: Deschênes-Simard, Xavier, Lessard, Frédéric, Gaumont-Leclerc, Marie-France, Bardeesy, Nabeel, Ferbeyre, Gerardo
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2014
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111748/
https://ncbi.nlm.nih.gov/pubmed/24866342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29335
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