Circumventing senescence is associated with stem cell properties and metformin sensitivity

Most cancers arise in old individuals, which also accumulate senescent cells. Cellular senescence can be experimentally induced by expression of oncogenes or telomere shortening during serial passage in culture. In vivo, precursor lesions of several cancer types accumulate senescent cells, which are...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Deschênes‐Simard, Xavier, Parisotto, Maxime, Rowell, Marie‐Camille, Le Calvé, Benjamin, Igelmann, Sebastian, Moineau‐Vallée, Karine, Saint‐Germain, Emmanuelle, Kalegari, Paloma, Bourdeau, Véronique, Kottakis, Filippos, Bardeesy, Nabeel, Ferbeyre, Gerardo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413657/
https://ncbi.nlm.nih.gov/pubmed/30614183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12889
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