Circumventing senescence is associated with stem cell properties and metformin sensitivity

Most cancers arise in old individuals, which also accumulate senescent cells. Cellular senescence can be experimentally induced by expression of oncogenes or telomere shortening during serial passage in culture. In vivo, precursor lesions of several cancer types accumulate senescent cells, which are...

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Dades bibliogràfiques
Publicat a:Aging Cell
Autors principals: Deschênes‐Simard, Xavier, Parisotto, Maxime, Rowell, Marie‐Camille, Le Calvé, Benjamin, Igelmann, Sebastian, Moineau‐Vallée, Karine, Saint‐Germain, Emmanuelle, Kalegari, Paloma, Bourdeau, Véronique, Kottakis, Filippos, Bardeesy, Nabeel, Ferbeyre, Gerardo
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Original Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413657/
https://ncbi.nlm.nih.gov/pubmed/30614183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12889
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