Circumventing senescence is associated with stem cell properties and metformin sensitivity

Most cancers arise in old individuals, which also accumulate senescent cells. Cellular senescence can be experimentally induced by expression of oncogenes or telomere shortening during serial passage in culture. In vivo, precursor lesions of several cancer types accumulate senescent cells, which are...

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Bibliographic Details
Published in:Aging Cell
Main Authors: Deschênes‐Simard, Xavier, Parisotto, Maxime, Rowell, Marie‐Camille, Le Calvé, Benjamin, Igelmann, Sebastian, Moineau‐Vallée, Karine, Saint‐Germain, Emmanuelle, Kalegari, Paloma, Bourdeau, Véronique, Kottakis, Filippos, Bardeesy, Nabeel, Ferbeyre, Gerardo
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Original Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413657/
https://ncbi.nlm.nih.gov/pubmed/30614183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12889
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