Circumventing senescence is associated with stem cell properties and metformin sensitivity

Most cancers arise in old individuals, which also accumulate senescent cells. Cellular senescence can be experimentally induced by expression of oncogenes or telomere shortening during serial passage in culture. In vivo, precursor lesions of several cancer types accumulate senescent cells, which are...

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Veröffentlicht in:Aging Cell
Hauptverfasser: Deschênes‐Simard, Xavier, Parisotto, Maxime, Rowell, Marie‐Camille, Le Calvé, Benjamin, Igelmann, Sebastian, Moineau‐Vallée, Karine, Saint‐Germain, Emmanuelle, Kalegari, Paloma, Bourdeau, Véronique, Kottakis, Filippos, Bardeesy, Nabeel, Ferbeyre, Gerardo
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413657/
https://ncbi.nlm.nih.gov/pubmed/30614183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12889
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