Satb1 regulates hematopoietic stem cell self-renewal by promoting quiescence and repressing differentiation commitment

How hematopoietic stem cells coordinate the regulation of opposing cellular mechanisms like self-renewal and differentiation commitment remains unclear. Here, we identified the transcription factor and chromatin remodeler Satb1 as a critical regulator of the hematopoietic stem cell (HSC) fate. HSCs...

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Autori principali: Will, Britta, Vogler, Thomas O., Bartholdy, Boris, Garrett-Bakelman, Francine, Mayer, Jillian, Barreyro, Laura, Pandolfi, Ashley, Todorova, Tihomira I., Okoye-Okafor, Ujunwa C., Stanley, Robert F., Bhagat, Tushar D., Verma, Amit, Figueroa, Maria E., Melnick, Ari, Roth, Michael, Steidl, Ulrich
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633104/
https://ncbi.nlm.nih.gov/pubmed/23563689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2572
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