Defining the Conformational Features of Anchorless, Poorly Neuroinvasive Prions

Infectious prions cause diverse clinical signs and form an extraordinary range of structures, from amorphous aggregates to fibrils. How the conformation of a prion dictates the disease phenotype remains unclear. Mice expressing GPI-anchorless or GPI-anchored prion protein exposed to the same infecti...

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Detalhes bibliográficos
Main Authors: Bett, Cyrus, Kurt, Tim D., Lucero, Melanie, Trejo, Margarita, Rozemuller, Annemieke J., Kong, Qingzhong, Nilsson, K. Peter R., Masliah, Eliezer, Oldstone, Michael B., Sigurdson, Christina J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630170/
https://ncbi.nlm.nih.gov/pubmed/23637596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003280
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