Biochemical Properties of Highly Neuroinvasive Prion Strains

Infectious prions propagate from peripheral entry sites into the central nervous system (CNS), where they cause progressive neurodegeneration that ultimately leads to death. Yet the pathogenesis of prion disease can vary dramatically depending on the strain, or conformational variant of the aberrant...

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Autores principales: Bett, Cyrus, Joshi-Barr, Shivanjali, Lucero, Melanie, Trejo, Margarita, Liberski, Pawel, Kelly, Jeffery W., Masliah, Eliezer, Sigurdson, Christina J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271082/
https://ncbi.nlm.nih.gov/pubmed/22319450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002522
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