Biochemical Properties of Highly Neuroinvasive Prion Strains

Infectious prions propagate from peripheral entry sites into the central nervous system (CNS), where they cause progressive neurodegeneration that ultimately leads to death. Yet the pathogenesis of prion disease can vary dramatically depending on the strain, or conformational variant of the aberrant...

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Detalhes bibliográficos
Main Authors: Bett, Cyrus, Joshi-Barr, Shivanjali, Lucero, Melanie, Trejo, Margarita, Liberski, Pawel, Kelly, Jeffery W., Masliah, Eliezer, Sigurdson, Christina J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271082/
https://ncbi.nlm.nih.gov/pubmed/22319450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002522
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