Enhanced neuroinvasion by smaller, soluble prions

Infectious prion aggregates can propagate from extraneural sites into the brain with remarkable efficiency, likely transported via peripheral nerves. Yet not all prions spread into the brain, and the physical properties of a prion that is capable of transit within neurons remain unclear. We hypothes...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Bett, Cyrus, Lawrence, Jessica, Kurt, Timothy D., Orru, Christina, Aguilar-Calvo, Patricia, Kincaid, Anthony E., Surewicz, Witold K., Caughey, Byron, Wu, Chengbiao, Sigurdson, Christina J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399838/
https://ncbi.nlm.nih.gov/pubmed/28431576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0430-z
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