Biochemical Properties of Highly Neuroinvasive Prion Strains

Infectious prions propagate from peripheral entry sites into the central nervous system (CNS), where they cause progressive neurodegeneration that ultimately leads to death. Yet the pathogenesis of prion disease can vary dramatically depending on the strain, or conformational variant of the aberrant...

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Main Authors: Bett, Cyrus, Joshi-Barr, Shivanjali, Lucero, Melanie, Trejo, Margarita, Liberski, Pawel, Kelly, Jeffery W., Masliah, Eliezer, Sigurdson, Christina J.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271082/
https://ncbi.nlm.nih.gov/pubmed/22319450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002522
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