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Structure of the β2-α2 loop and interspecies prion transmission

Prions are misfolded, aggregated conformers of the prion protein that can be transmitted between species. The precise determinants of interspecies transmission remain unclear, although structural similarity between the infectious prion and host prion protein is required for efficient conversion to t...

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Detalhes bibliográficos
Main Authors: Bett, Cyrus, Fernández-Borges, Natalia, Kurt, Timothy D., Lucero, Melanie, Nilsson, K. Peter R., Castilla, Joaquín, Sigurdson, Christina J.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382101/
https://ncbi.nlm.nih.gov/pubmed/22490928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-200923
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