A molecular switch controls interspecies prion disease transmission in mice

Transmissible spongiform encephalopathies are lethal neurodegenerative disorders that present with aggregated forms of the cellular prion protein (PrP(C)), which are known as PrP(Sc). Prions from different species vary considerably in their transmissibility to xenogeneic hosts. The variable transmis...

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Detalhes bibliográficos
Main Authors: Sigurdson, Christina J., Nilsson, K. Peter R., Hornemann, Simone, Manco, Giuseppe, Fernández-Borges, Natalia, Schwarz, Petra, Castilla, Joaquín, Wüthrich, Kurt, Aguzzi, Adriano
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898603/
https://ncbi.nlm.nih.gov/pubmed/20551516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42051
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