Spongiform Encephalopathy in Transgenic Mice Expressing a Point Mutation in the β2–α2 Loop of the Prion Protein

Transmissible spongiform encephalopathies are fatal neurodegenerative diseases attributed to misfolding of the cellular prion protein, PrP(C), into a β-sheet-rich, aggregated isoform, PrP(Sc). We previously found that expression of mouse PrP with the two amino acid substitutions S170N and N174T, whi...

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Main Authors: Sigurdson, Christina J., Joshi-Barr, Shivanjali, Bett, Cyrus, Winson, Olivia, Manco, Giuseppe, Schwarz, Petra, Rülicke, Thomas, Nilsson, K. Peter R., Margalith, Ilan, Raeber, Alex, Peretz, David, Hornemann, Simone, Wüthrich, Kurt, Aguzzi, Adriano
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205959/
https://ncbi.nlm.nih.gov/pubmed/21957246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3504-11.2011
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